E-commerce has gained significant attention in recent years, particularly in industries like healthcare and Industry 4.0. This interdisciplinary field can be explored from various perspectives, including technology, e-commerce, economics, and management. Future research topics and questions are proposed based on the analysis results and suggestions provided by authors in the same research field. This study aims to expose research endeavors in different regions, authors, and domains, identify main themes, and help big data analysts and scientists find innovative digital solutions for organizations and governments. The research has included a global perspective of innovative E-commerce adoption through longitudinal research, cross-cultural studies, business and economic level research, and qualitative method. National culture plays a role in environmental innovation through the use of Big Data Analytics capabilities. The future of e-commerce is bright with possibilities driven by technological advancements, and businesses need to adapt to stay ahead of the curve.