U.S. sanctions' extraterritorial reach has drawn significant attention in the field of international trade law, impacting diplomatic ties and international business activities. This study examines the effects of US sanctions on organizations and people not subject to US law, evaluating the legal ramifications of such actions within the context of international trade law. The study explores how these penalties penetrate international borders, looking at executive and legislative measures including the Foreign Corrupt Practices Act (FCPA) and the Office of Foreign Assets Control (OFAC) rules. The paper uses case studies of Iran, Russia and China to illustrate how extraterritorial U.S. sanctions impact global trade, corporate behavior, and legal responses. Additionally, quantitative data from global institutions assess their economic effects on trade, investment, and supply chains. The study concludes by exploring the legal tensions between U.S. sanctions and international trade law, offering policy recommendations for balancing sanctions with global legal norms. The analysis focuses on essential case studies where foreign entities, such as financial institutions and multinational enterprises, have been severely harmed by U.S. sanctions, leading to legal and compliance issues in multiple jurisdictions. This article clarifies how these sanctions alter the dynamics of international commerce, impose compliance obligations on multinational corporations, and potentially violate natio...